Difference between revisions of "Bioinformatics Software"

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'''Python packages mainly from Bioconda channel for the Conda package manager which specializes in bioinformatics software'''
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Revision as of 15:08, 18 June 2020

Python packages mainly from Bioconda channel for the Conda package manager which specializes in bioinformatics software

Name Description
Bamtools BamTools provides both a programmer's API and an end-user's toolkit for handling BAM files
Bedops BEDOPS is an open-source command-line toolkit that performs highly efficient and scalable Boolean and other set operations, statistical calculations, archiving, conversion and other management of genomic data of arbitrary scale. Tasks can be easily split by chromosome for distributing whole-genome analyses across a computational cluster.
Bedtools A swiss-army knife of tools for a wide-range of genomics analysis tasks. The most widely-used tools enable genome arithmetic: that is, set theory on the genome. For example, bedtools allows one to intersect, merge, count, complement, and shuffle genomic intervals from multiple files in widely-used genomic file formats such as BAM, BED, GFF/GTF, VCF
Biscuit A utility for analyzing sodium bisulfite conversion-based DNA methylation/modification data
Bismark A program to map bisulfite treated sequencing reads to a genome of interest and perform methylation calls in a single step. The output can be easily imported into a genome viewer, such as SeqMonk, and enables a researcher to analyse the methylation levels of their samples straight away
Boost & Boost-cpp Boost provides free peer-reviewed portable C++ source libraries
Bsmap BSMAP is a short reads mapping software for bisulfite sequencing reads. Bisulfite treatment converts unmethylated Cytosines into Uracils (sequenced as Thymine) and leave methylated Cytosines unchanged, hence provides a way to study DNA cytosine methylation at single nucleotide resolution. BSMAP aligns the Ts in the reads to both Cs and Ts in the reference
Cellranger Cell Ranger is a set of analysis pipelines that process Chromium single-cell RNA-seq output to align reads, generate feature-barcode matrices and perform clustering and gene expression analysis. Cell Ranger includes four pipelines relevant to single-cell gene expression experiments
Circos Circos is a software package for visualizing data and information. It visualizes data in a circular layout — this makes Circos ideal for exploring relationships between objects or positions
Darts Deep-learning Augmented RNA-seq analysis of Transcript Splicing
Eigensoft The EIGENSTRAT method uses principal components analysis to explicitly model ancestry differences between cases and controls along continuous axes of variation; the resulting correction is specific to a candidate marker’s variation in frequency across ancestral populations, minimizing spurious associations while The EIGENSOFT package has a built-in plotting script and supports multiple file formats and quantitative phenotypesmaximizing power to detect true associations.
Emase Expectation-Maximization algorithm for Allele Specific Expression
Finestruc fineSTRUCTURE is a fast and powerful algorithm for identifying population structure using dense sequencing data
Gatk The GATK is the industry standard for identifying SNPs and indels in germline DNA and RNAseq data
Gatk4 The GATK is the industry standard for identifying SNPs and indels in germline DNA and RNAseq data
Gsl The GNU Scientific Library (GSL) is a numerical library for C and C++ programmers
Homer Software for motif discovery and next generation sequencing analysis
Igblast A tool for analyzing immunoglobulin (IG) and T cell receptor (TR) sequences
Igv Integrative Genomics Viewer. Fast, efficient, scalable visualization tool for genomics data and annotations
Igvtools command line tools for IGV
Macs2 Model Based Analysis for ChIP-Seq data
Mafft Multiple alignment program for amino acid or nucleotide sequences
Meme Motif based sequence Analysis tools
Mirdeep2 A completely overhauled tool which discovers microRNA genes by analyzing sequenced RNAs
Peakachu Peak calling tool for CLIP-seq data
Plink Whole genome association analysis toolset, designed to perform a range of basic, large-scale analyses in a computationally efficient manner
r-ichorcna Estimating tumor fraction in cell-free DNA from ultra-low-pass whole genome sequencing
Rmats MATS is a computational tool to detect differential alternative splicing events from RNA-Seq data
Salmon Highly-accurate & wicked fast transcript-level quantification from RNA-seq reads using selective alignment
Tetoolkit Tools for estimating differential enrichment of Transposable Elements and other highly repetitive regions
Tobias TOBIAS - Transcription factor Occupancy prediction By Investigation of ATAC-seq Signal
Viennarna Vienna RNA package -- RNA secondary structure prediction and comparison
Weblogo Web based application designed to make the generation of sequence logos as easy and painless as possible

Name Description
Annovar ANNOVAR is an efficient software tool to utilize update-to-date information to functionally annotate genetic variants detected from diverse genomes (including human genome hg18, hg19, hg38, as well as mouse, worm, fly, yeast and many others)
Bcl2fastq bcl2fastq Conversion Software both demultiplexes data and converts BCL files generated by Illumina sequencing systems to standard FASTQ file formats for downstream analysis
BroadPeak BroadPeak calling algorithm for diffuse ChIP-seq datasets
CellPhoneDB CellPhoneDB is a publicly available repository of curated receptors, ligands and its interactions
Chimerax UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program
IBAMR IBAMR is a distributed-memory parallel implementation of the immersed boundary (IB) method with support for Cartesian grid adaptive mesh refinement (AMR)
Mega2 “Manipulation Environment for Genetic Analyses” A data-handling program for facilitating genetic linkage and association analyses
miRExpress Analyzing high-throughput sequencing data for profiling microRNA expression
Mochiview MochiView is Java software that integrates browsing of genomic sequences, features, and data with DNA motif visualization and analysis
Relion RELION (for REgularised LIkelihood OptimisatioN, pronounce rely-on) is a stand-alone computer program that employs an empirical Bayesian approach to refinement of (multiple) 3D reconstructions or 2D class averages in electron cryo-microscopy (cryo-EM)
Sratoolkit A set of compiled binaries and corresponding source code for tools that download, manipulate and validate next-generation sequencing data stored in the NCBI SRA archive
STAR Spliced Transcripts Alignment to a Reference
trim_galore Trim Galore! is a wrapper script to automate quality and adapter trimming as well as quality